SharePoint Execution permission cannot be required

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SQL-Server-2012

SharePoint2010

, +

Can i get with the following error?
Execution permission cannot be acquired.
Description: An unhandled exception occurred during the execution of the current web request. Please review the stack trace for more information about the error and where it originated in the code.

Exception Details: System.Security.Policy.PolicyException: Execution permission cannot be acquired.

Source Error:

An unhandled exception was generated during the execution of the current web request. Information regarding the origin and location of the exception can be identified using the exception stack trace below.

Stack Trace:


[PolicyException: Execution permission cannot be acquired.]
System.Security.SecurityManager.ResolvePolicy(Evidence evidence, PermissionSet reqdPset, PermissionSet optPset, PermissionSet denyPset, PermissionSet& denied, Boolean checkExecutionPermission) +10246216
System.Security.SecurityManager.ResolvePolicy(Evidence evidence, PermissionSet reqdPset, PermissionSet optPset, PermissionSet denyPset, PermissionSet& denied, Int32& securitySpecialFlags, Boolean checkExecutionPermission) +97

[FileLoadException: Could not load file or assembly 'Ajax, Version=5.7.20.2, Culture=neutral, PublicKeyToken=null' or one of its dependencies. Failed to grant permission to execute. (Exception from HRESULT: 0x80131418)]
System.Reflection.Assembly._nLoad(AssemblyName fileName, String codeBase, Evidence assemblySecurity, Assembly locationHint, StackCrawlMark& stackMark, Boolean throwOnFileNotFound, Boolean forIntrospection) +0
System.Reflection.Assembly.InternalLoad(AssemblyName assemblyRef, Evidence assemblySecurity, StackCrawlMark& stackMark, Boolean forIntrospection) +416
System.Reflection.Assembly.InternalLoad(String assemblyString, Evidence assemblySecurity, StackCrawlMark& stackMark, Boolean forIntrospection) +166
System.Reflection.Assembly.Load(String assemblyString) +35
System.Web.Configuration.CompilationSection.LoadAssemblyHelper(String assemblyName, Boolean starDirective) +190

[ConfigurationErrorsException: Could not load file or assembly 'Ajax, Version=5.7.20.2, Culture=neutral, PublicKeyToken=null' or one of its dependencies. Failed to grant permission to execute. (Exception from HRESULT: 0x80131418)]
System.Web.Configuration.CompilationSection.LoadAssemblyHelper(String assemblyName, Boolean starDirective) +11326376
System.Web.Configuration.CompilationSection.LoadAllAssembliesFromAppDomainBinDirectory() +388
System.Web.Configuration.CompilationSection.LoadAssembly(AssemblyInfo ai) +232
System.Web.Configuration.AssemblyInfo.get_AssemblyInternal() +48
System.Web.Compilation.BuildManager.GetReferencedAssemblies(CompilationSection compConfig) +210
System.Web.Compilation.BuildProvidersCompiler..ctor(VirtualPath configPath, Boolean supportLocalization, String outputAssemblyName) +76
System.Web.Compilation.CodeDirectoryCompiler.GetCodeDirectoryAssembly(VirtualPath virtualDir, CodeDirectoryType dirType, String assemblyName, StringSet excludedSubdirectories, Boolean isDirectoryAllowed) +11315554
System.Web.Compilation.BuildManager.CompileCodeDirectory(VirtualPath virtualDir, CodeDirectoryType dirType, String assemblyName, StringSet excludedSubdirectories) +185
System.Web.Compilation.BuildManager.EnsureTopLevelFilesCompiled() +551

[HttpException (0x80004005): Could not load file or assembly 'Ajax, Version=5.7.20.2, Culture=neutral, PublicKeyToken=null' or one of its dependencies. Failed to grant permission to execute. (Exception from HRESULT: 0x80131418)]
System.Web.Compilation.BuildManager.ReportTopLevelCompilationException() +76
System.Web.Compilation.BuildManager.EnsureTopLevelFilesCompiled() +1012
System.Web.Hosting.HostingEnvironment.Initialize(ApplicationManager appManager, IApplicationHost appHost, IConfigMapPathFactory configMapPathFactory, HostingEnvironmentParameters hostingParameters) +1025

[HttpException (0x80004005): Could not load file or assembly 'Ajax, Version=5.7.20.2, Culture=neutral, PublicKeyToken=null' or one of its dependencies. Failed to grant permission to execute. (Exception from HRESULT: 0x80131418)]
System.Web.HttpRuntime.FirstRequestInit(HttpContext context) +11420374
System.Web.HttpRuntime.EnsureFirstRequestInit(HttpContext context) +88
System.Web.HttpRuntime.ProcessRequestNotificationPrivate(IIS7WorkerRequest wr, HttpContext context) +4405156