Whic One is the best way avoid page load in asp.ent Website

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As you can see in this (very) simple example, the difference between the implementing a async callback with the toolkit and jQuery gives us an advantage of 951 characters. You can imagine what the difference would be in a page with let’s say 50 controls on their.

For simple Ajax functionality the toolkit is an excellent choice for a beginning developer. A developer who doesn’t want to know what’s going on in the background. He updates a drop down list and the correct value appears in the textbox underneath. What triggered it and how it’s used, he (or she) doesn’t care.

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Short answer:

If your page/site isn't currently depending on the UpdatePanel or ACT controls, definitely use jQuery and jQuery UI for any new work. That's even Microsoft's own recommendation now.