Save PDF file using itextsharp in asp.net

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ASP.NET

How to save directly PDF file to particulat folder using itextsharp in asp.net.please help me.
Below is the code :

Response.ContentType = "application/pdf";
                    Response.AddHeader("content-disposition",
                     "attachment;filename=In/Outreportfor_a_particular_Contract_Worker.pdf");
                    Response.Cache.SetCacheability(HttpCacheability.NoCache);
                    StringWriter sw = new StringWriter();
                    HtmlTextWriter hw = new HtmlTextWriter(sw);
                    GV.RenderControl(hw);
                    StringReader sr = new StringReader(sw.ToString());
                    Document pdfDoc = new Document(PageSize.A4);
                    Anchor target = new Anchor("In/Out report for a particular Contract Worker ");
                    target.Name = "target";
                    Paragraph p = new Paragraph();
                    p.Alignment = Element.ALIGN_CENTER;
                    p.SpacingAfter = 10f;
                    p.Add(target);
                    Anchor target1 = new Anchor("CW Code: " + txtcontractworker.Text + " ");
                    target1.Name = "target1";
                    Paragraph p1 = new Paragraph();
                    p1.Alignment = Element.ALIGN_LEFT;
                    p1.SpacingAfter = 8f;
                    p1.Add(target1);
                   HTMLWorker htmlparser = new HTMLWorker(pdfDoc);
                    PdfWriter.GetInstance(pdfDoc, Response.OutputStream);
                    pdfDoc.Open();
                    pdfDoc.Add(p);
                    pdfDoc.Add(p1);                
                    htmlparser.Parse(sr);
                    pdfDoc.Close();                   
                    Response.Write(pdfDoc);
                    Response.End();

In this code how to save the Downloaded PDF file particular folder.