Plot PDF x and y co-ordinates with new height and width

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I'm generating a Export PDF using DebenuPDF library, my question is not related to Debenu.

In my web page I will render tiff file with static height and width. In the Tiff file user can add the annotation. Height and width example as shown below

Page Height = 600
Page Width = 400

While the user plotting the annotation I was capturing the X and Y co-ordinates

X co-ordinate = 121.25
Y co-ordinate = 325.90

While exporting the pdf I have to do it in original size of tiff file what the user uploaded such as

Page Height = 1210
Page Width = 1650

I want to know plot the annotation where the user plotted. While exporting the PDF annotations are plotted with old X and Y co-ordinates so its pointing to some other places

Please anybody suggest the formula to calculate the X and Y co-ordinates with new height and width.