<textbox id='txtsave' ></textbox> <asp:requiredfieldvalidator id='' validationgroup='save'></asp:requiredfieldvalidator> <asp:requiredfieldvalidator id='' validationgroup='save1'></asp:requiredfieldvalidator> <asp:button validationgroup='save'> now onclick of your radiobutton change validation group of button so second validations will be work
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