How to Disable panels in chrome browser using Jquery

An asp:Panel just produces a div element. This isn't a form control, it's just there for structure.

To disable every input control inside of it, if you are using jQuery, try:

$("#<%=mypanel.ClientID%> input").attr("disabled", true);
Or plain ol' JavaScript:

var controls = document.getElementById("<%=mypanel.ClientID%>").getElementsByTagName("input");

for (var i = 0; i < controls.length; i++)
    controls[i].disabled = true;