IIS and uploading issue in asp.net

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IIS6

ASP.NET

SQL-Server

IIS

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Hi all,

From last 40 hours i am facing weird issue.
I have an application with asp.net 3.5 and back end as sql server 2008.
There is a page on which i am loading excel file to gridview and then uploading data from gridview to sql server.
It works perfectly on local machine, also on IIS.

Issue is:
After uploading excel file multiple times i get error.
Error is: system.exception error in initializing oledbconnectioncomes and it goes once i reset IIS.

Please suggest some valuable tips/solution to solve this as it is not feasible to reset IIS again and again.

Error that comes: System.Exception: error in initializing oledbconnection

Thanks