A generic error occurred in GDI+ upon pressing Hotkey

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VB

VB10

I manage to publish my my program to project. Its partially working. When I try to use Hot key function ALT Z, (To capture image) this error appears:
Seriously I don't know what to do next. It seems working before I publish it without wany warning or errors.

See the end of this message for details on invoking 
just-in-time (JIT) debugging instead of this dialog box.
************** Exception Text **************
System.Runtime.InteropServices.ExternalException (0x80004005): A generic error occurred in GDI+.
   at System.Drawing.Image.Save(String filename, ImageCodecInfo encoder, EncoderParameters encoderParams)
   at System.Drawing.Image.Save(String filename, ImageFormat format)
   at WindowsApplication1.frmmain.WndProc(Message& m)
   at System.Windows.Forms.Control.ControlNativeWindow.OnMessage(Message& m)
   at System.Windows.Forms.Control.ControlNativeWindow.WndProc(Message& m)
   at System.Windows.Forms.NativeWindow.Callback(IntPtr hWnd, Int32 msg, IntPtr wparam, IntPtr lparam)

This the place where I save the image: From my reading, it is well said that If the image is locked that this will happen. But I don't have any idea what does it mean. Please let me know if you guys need some more details.

Protected Overrides Sub WndProc(ByRef m As System.Windows.Forms.Message)

      If m.Msg = WM_HOTKEY Then
         Dim id As IntPtr = m.WParam
         Select Case (id.ToString)
            Case "100"
               ' Button2_Click(Nothing, Nothing)
               'add 07/02/11
               imagename = Replace(Now.Date, "/", "") & "-" & Int(Now.TimeOfDay.TotalSeconds)
               sc.CaptureScreen.Save("sc1/" & imagename & ".jpg", System.Drawing.Imaging.ImageFormat.Jpeg)


               con.Open()
               Dim rs As New OleDb.OleDbCommand("INSERT INTO tblcapture (imagename) VALUES ('" & imagename & "')", con)
               rs.ExecuteNonQuery()
               con.Close()

               stat = 2
               AddHandler NotifyIcon1.BalloonTipClicked, AddressOf NotifyIcon1_BalloonTipClicked
               Me.NotifyIcon1.BalloonTipIcon = ToolTipIcon.Info  ' Info on the balloon. you can change it to warning or error type as welll
               Me.NotifyIcon1.BalloonTipText = " You have successfully saved the Screen Capture" & vbCrLf & " then click the notification to proceed"
               Me.NotifyIcon1.BalloonTipTitle = " U-Surf System Notification"
               Me.NotifyIcon1.ShowBalloonTip(10)

               frmQuestionnaire.lblimage.Text = imagename

               ' add 09/02/2011 
               '  frmqlist.UpdateListView()
               frmQuestionnaire.UpdateListView()

               'frmQuestionnaire.Show()
               Me.pmain.Show()
               ' me.Hide()
               Me.WindowState = FormWindowState.Minimized

               '   Form2.Show()
         End Select

      End If
      MyBase.WndProc(m)
   End Sub

I forgot to mention I am using Icon changed when user hover to the image. at the image can be viewed based on this:-

If Me.PictureBox1.SizeMode = PictureBoxSizeMode.AutoSize Then
      Me.PictureBox1.Dock = DockStyle.Fill
      Me.PictureBox1.SizeMode = PictureBoxSizeMode.Zoom
    Else
      Me.PictureBox1.Dock = DockStyle.None
      Me.PictureBox1.SizeMode = PictureBoxSizeMode.AutoSize
      'Display center-part of the image
      Dim pbs As Size = Me.PictureBox1.ClientSize
      Dim p1s As Size = Me.Panel1.ClientSize
      Me.Panel1.AutoScrollPosition = New Point((pbs.Width - p1s.Width) \ 2, (pbs.Height - p1s.Height) \ 2)
    End If

I Really need help so that I am able to run this program. This program only involve 3 forms. Upon clicking the hotkey error occurs.
I hope anyone can guide me on this

Thank you.