Start by looking at exactly what file path you are trying to open.
Dim path as String = My.Computer.FileSystem.CurrentDirectory & "\SymCorpUI.exe"
Process.Start(path);
Put a breakpoint on the Process.Start line, and run your app in the debugger. When it hits, look at the content of path.
It should be the full path to the executable, so check that folder holds the file. If it doesn't, then you need to specify a different folder ...