You need to use interop services. This should get you started:
using System.Runtime.InteropServices;
llImport("user32.dll")]
static extern void mouse_event(int dwFlags, int dx, int dy,
int dwData, int dwExtraInfo);
[Flags]
public enum MouseEventFlags
{
LEFTDOWN = 0x00000002,
LEFTUP = 0x00000004,
MIDDLEDOWN = 0x00000020,
MIDDLEUP = 0x00000040,
MOVE = 0x00000001,
ABSOLUTE = 0x00008000,
RIGHTDOWN = 0x00000008,
RIGHTUP = 0x00000010
}
public static void LeftClick(int x, int y)
{
Cursor.Position = new System.Drawing.Point(x, y);
mouse_event((int)(MouseEventFlags.LEFTDOWN), 0, 0, 0, 0);
mouse_event((int)(MouseEventFlags.LEFTUP), 0, 0, 0, 0);
}