How to recall the initialize_request function and end_request function of sys.webforms.pagerequestmanager.getinstance();

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VB

ASP.NET

Javascript

Ajax

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I have a save button , inside codebehind of that button i call a javascript function using ScriptManager.RegisterClientScriptBlock() , inside this javascript function i show a conformation popup and again click the button using javascript but it does not initialize ajax request .
Because inside initialize_request function and end_request function of Sys.WebForms.PageRequestManager.getInstance() ,i have to locked the form control but it does not work.
Inside Lock form function i disable the buttons of the page and call document.body.style.cursor = 'wait';

What I have tried:

i recall the lock form control function but it did not work