Thankyou it put me on the right path to a Solution.
using System;
using System.Data;
using System.Configuration;
using System.Web;
using System.Web.Security;
using System.Web.UI;
using System.Web.UI.WebControls;
using System.Web.UI.WebControls.WebParts;
using System.Web.UI.HtmlControls;
using System.IO;
public partial class Default : System.Web.UI.Page
{
protected void DropDownList1_SelectedIndexChanged(object sender, EventArgs e)
{
string filePath = Request.PhysicalApplicationPath + "attachments/" + DropDownList1.SelectedValue + ".pdf";
FileInfo imageFile = new FileInfo(filePath);
bool fileExists = imageFile.Exists;
if (fileExists == false)
ShowPdf1.FilePath = "attachments/Nofile.pdf#toolbar=0&navpanes=0&zoom=100";
else
ShowPdf1.FilePath = "attachments/" + DropDownList1.SelectedValue + ".pdf#toolbar=0&navpanes=0&zoom=50";
}
}