ASP.NET

string newPathToSave = @"F:\Education\Education\Images\Thumbnail\sample.jpg";
            MemoryStream memory = new MemoryStream(File.ReadAllBytes(@"F:\Education\Education\Images\run.png"));
            //imgNameSpace  img = imgNameSpace.FromStream(memory);
            System.Drawing.Image img = System.Drawing.Image.FromStream(memory, true);
            System.Drawing.Bitmap bmpResized = new System.Drawing.Bitmap(img, 248, 80);
            bmpResized.Save(memory, img.RawFormat);
            bmpResized.Save(newPathToSave);
            img.Dispose();
            bmpResized.Dispose();
            myuser.SrcNews = newPathToSave;

System.Runtime.InteropServices.ExternalException was unhandled by user code
  Message="A generic error occurred in GDI+."
  Source="System.Drawing"
  ErrorCode=-2147467259
  StackTrace:
       at System.Drawing.Image.Save(String filename, ImageCodecInfo encoder, EncoderParameters encoderParams)
       at System.Drawing.Image.Save(String filename, ImageFormat format)
       at System.Drawing.Image.Save(String filename)
       at Education.WebForm5.sendNewsBtn_Click(Object sender, EventArgs e) in F:\Education\Education\sendNewsPage.aspx.cs:line 56
       at System.Web.UI.WebControls.Button.OnClick(EventArgs e)
       at System.Web.UI.WebControls.Button.RaisePostBackEvent(String eventArgument)
       at System.Web.UI.WebControls.Button.System.Web.UI.IPostBackEventHandler.RaisePostBackEvent(String eventArgument)
       at System.Web.UI.Page.RaisePostBackEvent(IPostBackEventHandler sourceControl, String eventArgument)
       at System.Web.UI.Page.RaisePostBackEvent(NameValueCollection postData)
       at System.Web.UI.Page.ProcessRequestMain(Boolean includeStagesBeforeAsyncPoint, Boolean includeStagesAfterAsyncPoint)
  InnerException: 

string newPathToSave = @"F:\Education\Education\Images\Thumbnail\sample.png";
          MemoryStream memory = new MemoryStream(File.ReadAllBytes(@"F:\Education\Education\Images\run.png"));
          //imgNameSpace  img = imgNameSpace.FromStream(memory);
          System.Drawing.Image img = System.Drawing.Image.FromStream(memory, true);
          System.Drawing.Bitmap bmpResized = new System.Drawing.Bitmap(img, 248, 80);
          bmpResized.Save(memory, img.RawFormat);
          bmpResized.Save(newPathToSave);
          img.Dispose();
          bmpResized.Dispose();
          myuser.SrcNews = newPathToSave;