i solved this issue
When Master Page is used the ASP.Net AJAX MultiSliderExtender is not able to find the HiddenField.
Do Page View Source and copy the ClientID of Hidden Fields.
<asp:MultiHandleSliderExtender ID="MultiHandleSliderExtender1" runat="server" TargetControlID="txtSlider"
Minimum="1" Maximum="1000" Increment="1" RaiseChangeOnlyOnMouseUp="true" EnableRailClick="false"
Length="1000" OnClientDragEnd="OnClientDragEnd">
<multihandleslidertargets>
<asp:MultiHandleSliderTarget ControlID="ContentPlaceHolder1_hfStart" />
<asp:MultiHandleSliderTarget ControlID="ContentPlaceHolder1_hfEnd" />
</multihandleslidertargets>
</asp:MultiHandleSliderExtender>