change the name of the method to
<asp:button id="btn" text="submit" runat="server" onclientclick="return onchange1();" xmlns:asp="#unknown" />
<script type="text/javascript">
function onchange1() {
debugger;
var vas = document.getElementById('<%=txt1.ClientID%>').value;
alert(vas);
var vas1 = document.getElementById('<%=txt1.ClientID%>').value;
if (vas.value == "") {
alert('pla enter address');
}
}
</script>
Now the event fires