This code will surely help you....
string path = @"D:\newS_R.txt";
using(StreamWriter sw = new StreamWriter(path,true))
{
sw.WriteLine(textBox46.Text + " " + textBox45.Text + " " + textBox44.Text + " " + textBox43.Text + " " + textBox42.Text + " " + textBox41.Text + " " + textBox40.Text + " " + textBox39.Text + " " + textBox38.Text + " " + textBox37.Text + " " + textBox33.Text + " " + textBox34.Text + " " + textBox35.Text + " " + textBox36.Text + "" + Environment.NewLine);
}