You have two different spellings for your connection object, which one is correct?
OleDbConnection _Connection = new OleDbConnection(sConnection);
_Connection.Open();
string cmd = string.Format("Update [{0}$A106880:A106880] set F1 = 12", sheetname);
System.Data.OleDb.OleDbCommand myCommand = new System.Data.OleDb.OleDbCommand(cmd, connection);