If your goal is to disable certain items in a ComboBox it can be done by using the DrawItem and SelectedIndexChanged event.
You also need to determine the logic for which item index(es) that should be grayed out.
Here is an example from StackOverflow
Disabling particular Items in a Combobox[
^] that you can use as a starting point.
I would not recommend to use hard coded indexes like in that example, though.
And if this is the right controls to use in order to implement your solution is a different story.