Update table after leaving data grid

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C#

I got a windows Form inside i got datagridview where i have connections with different DB tables .
----i have loaded a table in datagrid .
----i have implemented delete and add rows function which works perfectly fine
---i have also implemented Update function and call this update on dataGridView_CellValueChanged which also works perfectly fine.
--But the Problem is i got a toolstripDropdown button on my form so when i change something in my gridview and directly click on Tollstrip Button then dataGridView_CellValueChanged is not raised so my tabble is not updated.
It is clear that because no eventis raised my tableis not updated but i have tried with many other events but non of these seems to b working .
Anyone got any idea how to solve this.