Taking into account that the value of
TextBox.Text
can be empty but cannot be null, you can write a very simple condition:
bool isValid = Address1.Text + POBox.Text != string.Empty;
Perhaps you also need to treat a text which contains only blank space characters also as a control with missing data. In this case (which is really reasonable in most practical situations), the check would be a bit more complex:
bool isValid = Address1.Text.Trim() + POBox.Text.Trim() != string.Empty;
Good luck.
—SA