Another way is to define, let's say: 'translate table' or 'dictionary table'.
DECLARE @transtable TABLE (OrygValue VARCHAR(30), NewValue VARCHAR(30))
INSERT INTO @transtable (OrygValue, NewValue)
VALUES('Azure', 'AppPlat'),
('CRM', 'AppPlat'),
('Developer Tools', 'AppPlat'),
and so on...
Than you need to Join both tables:
UPDATE dstTbl SET [Quad Alignment] = srcTbl.NewValue
FROM #tempSDAT AS dstTbl INNER JOIN @transtable AS srcTbl ON dstTbl.[Quad Alignment] = @transtable.OrygValue
That's all :)