Just iterate through the loop of DataGridViewRows
private void button1_Click(object sender, EventArgs e)
{
decimal total = 0;
foreach (DataGridViewRow row in dataGridView1.Rows)
{
if (!row.IsNewRow && row.Cells["Total"].Value != null)
{
total += (decimal)row.Cells["Total"].Value;
}
}
label1.Text = total.ToString("N2");
}