If you mean that you want a text box where the user cannot modify some of the text, just add to the end (or similar) then the text box is not a good choice - it can't do it out of the box, and it would be "clumsy" to add that functionality.
However, there is the
MaskedTextBox[
^] which can: look at the Mask property.
For example, setting the Mask to "FIXED TEXT: AAAAA : MORE" means that the user can enter only 5 alphanumeric characters, which will always be in the area between the ':' characters.