Try this
SELECT DATEDIFF(dd, '3/26/2012', '3/28/2012') [Day Difference]
Result
Day Difference
2
Other datepart types
SELECT DATEDIFF(HH, '3/26/2012 3:30 PM', '3/26/2012 5:30 PM') [Hour Difference]
SELECT DATEDIFF(MINUTE, '3/26/2012 3:30 PM', '3/26/2012 5:30 PM') [minute difference]
Similary you can add keywords like Month, SS (Second), MS (millisecond), MCS (microsecond) for differences