if its a server side control. you need to set the virtual path.
Server.MapPath(".") returns the current physical directory of the file (e.g. aspx) being executed
Server.MapPath("..") returns the parent directory
Server.MapPath("~") returns the physical path to the root of the application
Server.MapPath("/") returns the physical path to the root of the domain name (is not necessarily the same as the root of the application)
use
string path = Server.MapPath("~") + "/Uploads/Chrysanthemum_3.jpeg"; <br />
imgPicture.ImageUrl = path;