use Trigger on Script Manager :
<asp:ScriptManager ID="sc1" runat="server">
</asp:ScriptManager>
<asp:UpdatePanel ID="u1" runat="server">
<ContentTemplate>
// your content
</ContentTemplate>
<Triggers>
<asp:PostBackTrigger ControlID="Submit" />
</Triggers>
</asp:UpdatePanel>
in Submit name give your Save or Submit button name.
This will help you.