The best way to do this is to manually enter the relevant skills into a table so that the resume is associated with a variety of skills:
Table - Clients
ID Int with Identity, or Guid
Resume Binary
other info on client.
Table - Skills
ID Int with Identity, or Guid
Skill Text
Table - ClientSkills
Id Int with Identity, or Guid
ClientID Foreign key to Clients table
SkillID Foreign key of Skills table
So id you have "known" skills:
Skills:
1 C++
2 C#
3 VB
4 Cobol
And you have Clients
1 Resume.docx Mike Smith
2 MyResume.docx John Doe
Then you would have ClientSkills:
1 1 1
2 1 3
3 2 2
4 2 3
You then find all C++ programmers with a simple JOIN:
SELECT c.* FROM Clients c
JOIN ClientSkills cs ON cs.ClientID = c.ID
JOIN Skills s ON cs.SkillID = s.ID
WHERE s.Skill = 'C++'