to create hot key there are 2 ways;-
1) by changing the text of your button with "&".Like if you have a button "Save" And want to create a hot key you can change the name by "&Save" that will create a hot ket (Alt + S).
2) by adding the hot key on
Form_KeyDown event
. Like
for save you want (Control + S) then write
if(e.Control == true && e.KeyData == Keys.S)
{
btnSave_Click(sender,e);
}