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i tried with small input and still get error.
Define what is a small input, the size.
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usually Genes are huge data, hundred of thousands of gene sequences.
If you are serious about this, you need to hire a skilled programmer.
Your app probably need a total reorganize in order to remove the memory problem and enhance the performance. The form of the data and your usage is also very important.
There is no way a few hints will really help you.
and no hint is possible without an extended explanation of how you did your app.