If it a normal
browser alert, then you cannot do that.
If the popup is one Modal one created in
jQuery, then you can restrict the previous page load by the following code.
<script type="text/javascript" language="javascript">
if (window.history.forward(1) != null)
{
window.history.forward(1);
}
</script>
If you really want to do that, then try to add one
jQuery Modal popup instead of browser
alert box.