Try:
Image i = Image.FromFile(@"F:\Temp\MyPic.tif");
Image cropped = new Bitmap(200, 200);
Graphics g = Graphics.FromImage(cropped);
Rectangle dest = new Rectangle(new Point(0, 0), cropped.Size);
Rectangle source = new Rectangle(new Point(100,100), cropped.Size);
g.DrawImage(i, dest, source, GraphicsUnit.Pixel);
g.Dispose();