Re-writng URL with global.asax causing issue on button click ASP.NET

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ASP.NET

I am using global file to rewrite URL, rewriting works fine for other url just one rule is not working which makes all ajax/button clicks stop. All my button clicks works fine when i use:

routes.MapPageRoute("BusinessDetails", "bd/{PageUrl}", "~/business-details.aspx")

but i dont want this type of url:

'www.mywebsite/com/bd/business'

i need this

'www.mywebsite.com/business'

for this am using

routes.MapPageRoute("BusinessDetails", "{PageUrl}", "~/business-details.aspx")

but this stops all button clicks though i get the needed url and site works just stops all button clicks/update pannel/validation.

I need this url to work with all button clicks
www.mywebsite/com/business or

www.mywebsite.com/business

www.mywebsite.com/business/

like this works in indiamart

What I have tried:

Tried using 'routes.Ignore("{webresource}.axd/{*pathInfo}")' for button click as was getting error in console 'Unexpected token <' in webresource.axd
Also tried

routes.MapPageRoute("BusinessDetails1", "{PageUrl}/{categoryName}", "~/business-details.aspx", false, New RouteValueDictionary(New With {.categoryName = "home"}))

And also when i click on button it says in console 'Page_ClientValidate is not defined'